Elanco Introduces NUPLURA PH+ for Cattle

The product offers proven performance against Mannheimia haemolytica, while adding protection against common viral causes of BRD, including BVD Types 1 and 2 and IBR.
The product offers proven performance against Mannheimia haemolytica, while adding protection against common viral causes of BRD, including BVD Types 1 and 2 and IBR.

Elanco Animal Health Incorporated ) brings the cattle industry powerful new options for fast, smooth and flexible protection against bovine respiratory disease (BRD)—one of the deadliest diseases affecting U.S. cattle.1
New NUPLURA PH+ builds on the proven performance of NUPLURA PH against Mannheimia haemolytica, while adding protection against common viral causes of BRD, including BVD Types 1 and 2 and IBR.
NUPLURA PH+ provides protective immunity against M. haemolytica in as little as 10 days, which is the fastest immunity claim on the market. M. haemolytica is the primary bacterial cause of pneumonia in cattle.2 NUPLURA PH+ protects against M. haemolytica and other causes of BRD in calves, as well as in animals at risk for BRD during weaning, branding, shipping, commingling and other times of elevated stress.
For cattle producers concerned about both bacterial and viral causes of BRD, these NUPLURA PH+ options provide additional protection:
•    NUPLURA PH+BVD delivers additional protection against BVD Types 1 and 2
•    NUPLURA PH+3 adds protection against BVD Types 1 and 2, plus IBR
“With NUPLURA PH+, the fastest BRD vaccine on the market just got better. Producers can now target bacterial and viral BRD pathogens with one vaccination. This means less stress on the animal, less labor and less time to administer,” says  Brett Terhaar, Elanco Animal Health technical consultant. “Producers have the flexibility to deliver the right protection their herds need, at the right time.”
In addition, NUPLURA PH+ is gentle and safe to use on animals as young as 28 days. Field trials show that calves vaccinated with NUPLURA PH+ stay on feed and water with minimal sweats or other setbacks.3 With few post-vaccination reactions to overcome, animals can devote energy to growth and productivity.
Two virulence factors
NUPLURA PH+ is the only M. haemolytica vaccine portfolio that combines recombinant leukotoxoid technology and purified outer membrane proteins (OMPs). These two virulence factors are key to the vaccine’s strong, smooth response.
Using recombinant technology to produce NUPLURA PH+ results in consistently high levels of pure leukotoxoid, which stimulates production of antibodies that bind and inhibit M. haemolytica leukotoxin and allow for a strong immune response. NUPLURA PH+ contains OMPs and is designed for minimal adverse reactions.

1 Griffin D. Economic impact associated with respiratory disease in beef cattle. Vet Clin North Am Food Animal Pract 1997;3:367-77
2 Irsik MB. Bovine respiratory disease associated with Mannheimia haemolytica or Pasteurella Multocida. Institute of Food and Agricultural Sciences Publication VM-163, University of Florida. Accessed June 7, 2012.
3 Elanco Animal Health. Data on file.



Latest News

Mastitis in Beef Cows: What You Need to Know

Although mastitis, an infection of the udder, is often considered a dairy cow problem, the disease may also impact beef producers. Here's what you need to know and look for and how to help protect your herd.

We Need More Answers, Veterinarian Says About Biosecurity Research

As a veterinarian, Jeremy Pittman, senior director of U.S. veterinary services for Smithfield Foods, says he is constantly tasked with, asked about and challenged on biosecurity processes or protocols. 

Mineral and Vitamin Considerations When Drylotting Cows

Managing cows in a drylot can be a way to maintain the herd when forage production is reduced. However, it's important to make sure cows are getting the vitamins and minerals they need.

Animal Activist and Former Baywatch Star Found Not Guilty in ‘Open Rescue’

Former “Baywatch” star Alexandra Paul and activist Alicia Santurio were found not guilty of misdemeanor theft after “rescuing” two chickens in 2021. Although they faced jail time, Paul says it was worth the risk.

7 Tips for More Effective Vaccination Programs in Calves

Ask 10 dairy producers what they believe is an effective vaccination program for calves, and you’ll likely get 10 unique answers. That’s OK, because there is no effective one-size-fits-all strategy.

For the Love of the Game, How Agriculture Helped Birth the Game of Basketball

It may not seem like basketball has a strong connection to agriculture, but from the balls used in the NBA, to the sport itself, agriculture has direct ties to a sport that takes over televisions during March Madness.