Generally, beef herd pregnancy rates after a 60–120-day breeding season tend to range from 80 to 94 percent. Pregnancy diagnosis identifies the 6–20 percent of open cows in the herd so they can be culled after their calves at side are weaned, instead of waiting to the end of the subsequent calving season. Considering that the annual feed/forage costs associated with maintaining a mature cow can be as high as $400 to $600 per year, culling open cows can save as much as $250 per head that can be diverted to the purchase or development of replacement females, sire selection, increased nutritional management, and other management-related costs. Pregnancy diagnosis can be performed simply at the time that producers work their cattle during their vaccination schedule or even at the time of weaning. There are three practical methods that can be utilized for pregnancy diagnosis in beef herds: 1) rectal palpation, 2) transrectal ultrasonography, or 3) use of a blood sample that is submitted to a laboratory for analysis and results returned to the producer within a few days.