The U.S. Department of Agriculture (USDA) has issued a Veterinary Biologics License for Titanium® 5 + PH-M, a new vaccine that protects cattle against the viruses and bacteria most associated with bovine respiratory disease (BRD).
Marketed by Elanco, Titanium® 5 + PH-M provides modified-live virus (MLV) protection against bovine viral diarrhea (BVD), types 1 and 2, bovine respiratory syncytial virus (BRSV), infectious bovine rhinotracheitis (IBR) and parainfluenza3 (PI3).1-9 Each dose also protects against Mannheimia haemolytica10 and Pasteurella multocida bacteria, and is safe for cattle at all stages of production.3,5-7,11-16
“This means veterinarians and producers can protect cattle against the important BRD-causing viruses and bacteria with just one vaccine,” says Brett Terhaar, D.V.M., Elanco beef technical services. Titanium® 5 + PH-M is well-suited for branding and weaning/preconditioning vaccination protocols in cow/calf operations, as well as arrival programs in stocker operations and feedyards. Producers should partner with their veterinarians to determine the best way to incorporate this new vaccine into herd-health protocols designed to fight BRD.”
Viruses and bacteria: a powerful one-two punch on the immune system
Respiratory viruses can cause BRD on their own, but they also can compromise the immune system that normally protects cattle against bacteria. This allows bacteria to attack their host and cause severe cases of BRD.
“When cattle are exposed to respiratory viruses, their immune system can be weakened,” says Terhaar. “Once that happens, M. haemolytica and P. multocida bacteria can more easily go deep into the respiratory tract. When they reach the lungs, bacterial pathogens are a major cause of serious BRD, leading to increased illness and death.”
BRD still is the No. 1 profit-robber, accounting for 75 percent of feedlot morbidity, and 50 percent to 75 percent of mortality, costing an estimated $800 million to $900 million annually.17-20 Beyond that, one study showed 68 percent of untreated calves had pulmonary lesions at slaughter — demonstrating that a significant number of animals never diagnosed with BRD do, in fact, suffer from some form of respiratory disease.21
A combination vaccine for convenience, effectiveness and safety
Titanium® 5 + PH-M is a combination of two trusted vaccines. Its viral component, Titanium® 5 + PH-M, delivers modified-live protection against five important viruses that cause BRD. Its PH-M component provides coverage against two bacteria that are well-known for causing pasteurellosis (part of the BRD complex).
The new vaccine is formulated with a low-reactive, water-soluble adjuvant. The result is a low-volume (2 mL), subcutaneous dose that is consistent with Beef Quality AssuranceSM (BQA) guidelines.
Approved for use in cattle 60 days of age and older, Titanium® 5 + PH-M is backed by noninterference, efficacy and safety research. It can be given to pregnant cows and heifers,* as well as calves nursing pregnant cows.**
“This means added flexibility as veterinarians and producers develop vaccine protocols to protect cattle at all stages of production against BRD,” says Terhaar. “Adding Titanium® 5 + PH-M to the portfolio of ViralignTM 6, Master Guard® and other Titanium brand vaccines gives a variety of choices for delivering protection against challenging diseases.”
Titanium® 5 + PH-M is available in convenient 10-dose and 50-dose packages through veterinarians and animal-health distributors. For more information, see the product label, contact your Elanco sales representative or technical consultant, or visit Elanco.us.
Elanco is a global innovation-driven company that develops and markets products to improve animal health and food animal production in more than 75 countries. Elanco employs more than 3,500 people worldwide, with offices in more than 40 countries, and is a division of Eli Lilly and Company, a leading global pharmaceutical corporation. Additional information about Elanco is available at www.elanco.com.